LMPD Database

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LMP007147

UniProt Annotations

Entry Information
Gene NameHst4p
Protein EntryHST4_YEAST
UniProt IDP53688
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityNAD(+) + an acetylprotein = nicotinamide + O- acetyl-ADP-ribose + a protein. {ECO:0000255|PROSITE- ProRule:PRU00236}.
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
CofactorName=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= ; Note=Binds 1 zinc ion per subunit. ;
FunctionNAD-dependent histone deacetylase, which contributes together with HST3 to histone H3 'Lys-56' deacetylation, regulation of telomeric silencing, proper cell cycle progression, DNA damage control, DNA recombination, and genomic maintenance. {ECO:0000269|PubMed:10841563, ECO:0000269|PubMed:16487579, ECO:0000269|PubMed:16815704, ECO:0000269|PubMed:17106263}.
MiscellaneousPresent with 377 molecules/cell in log phase SD medium
MiscellaneousPresent with 377 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the sirtuin family. Class I subfamily
SimilarityBelongs to the sirtuin family. Class I subfamily. {ECO:0000305}.
SimilarityContains 1 deacetylase sirtuin-type domain
SimilarityContains 1 deacetylase sirtuin-type domain. {ECO:0000255|PROSITE-ProRule:PRU00236}.
Subcellular LocationNucleus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:17106263}.