LMPD Database

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LMP007199

UniProt Annotations

Entry Information
Gene NameGpi8p
Protein EntryGPI8_YEAST
UniProt IDP49018
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionMediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein.
InteractionP39012:GAA1; NbExp=3; IntAct=EBI-7822, EBI-7252; P38875:GPI16; NbExp=3; IntAct=EBI-7822, EBI-24869;
MiscellaneousPresent with 1560 molecules/cell in log phase SD medium
MiscellaneousPresent with 1560 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayGlycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
PtmThe disulfide bond between GPI8 and GPI16 is important for normal enzyme activity
PtmThe disulfide bond between GPI8 and GPI16 is important for normal enzyme activity. {ECO:0000250}.
SimilarityBelongs to the peptidase C13 family
SimilarityBelongs to the peptidase C13 family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Single-pass type I membrane protein.
SubunitForms a complex with CDC91, GPI16, GPI17 and GAA1
SubunitForms a complex with CDC91, GPI16, GPI17 and GAA1. {ECO:0000269|PubMed:11598210}.