LMPD Database

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LMP007216

UniProt Annotations

Entry Information
Gene Namephosphatidate cytidylyltransferase
Protein EntryCDS1_YEAST
UniProt IDP38221
SpeciesYeast (S288c)
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=1 mM for CTP {ECO:0000269|PubMed:2822695}; KM=0.5 mM for phosphatidate {ECO:0000269|PubMed:2822695}; Vmax=4700 nmol/min/mg enzyme {ECO:0000269|PubMed:2822695}; pH dependence: Optimum pH is 6.5. {ECO:0000269|PubMed:2822695};
Catalytic ActivityCTP + phosphatidate = diphosphate + CDP- diacylglycerol. {ECO:0000269|PubMed:2822695}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:2822695};
FunctionSupplies CDP-diacylglycerol, which may play an important role as both a precursor to phosphoinositide biosynthesis in the plasma membrane and as a negative effector of phosphatidylinositol 4-kinase activity, thereby exerting an effect on cell proliferation via a lipid-dependent signal transduction cascade. {ECO:0000269|PubMed:2822695, ECO:0000269|PubMed:8557688}.
PathwayPhospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
SimilarityBelongs to the CDS family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle. Note=Exclusively present in the ER, and not in mitochondria. Also associated with post-Golgi apparatus secretory vesicles destined for the plasma membrane.
SubunitHomodimer.