LMPD Database

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LMP007218

UniProt Annotations

Entry Information
Gene NameTaz1p
Protein EntryTAZ1_YEAST
UniProt IDQ06510
SpeciesYeast (S288c)
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=7 uM for lysophosphatidylcholine;
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.
DomainThe HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine. {ECO:0000250}.
Enzyme RegulationInhibited by zinc and o-phenanthroline. {ECO:0000269|PubMed:9930410}.
FunctionAcyltransferase which mediates the conversion of 1-acyl- sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Displays a broad LPC fatty acyl chain substrate specificity utilizing LPC molecules ranging in length from C-10 to C-20. Does not utilize other lysolipids than LPC as acceptor. Also shows acyl-CoA-independent acyltransferase activity. Required for normal phospholipid content of mitochondrial membranes. Involved in the remodeling of the acyl groups of cardiolipin in the mitochondrial inner membrane, which affects the assembly and stability of respiratory chain complex IV and its supercomplex forms. {ECO:0000269|PubMed:14651618, ECO:0000269|PubMed:15588229, ECO:0000269|PubMed:16135531}.
MiscellaneousPresent with 1340 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the taffazin family. {ECO:0000305}.
Subcellular LocationMitochondrion outer membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}; Intermembrane side {ECO:0000305}.