LMPD Database

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LMP007224

UniProt Annotations

Entry Information
Gene Name1-acylglycerol-3-phosphate O-acyltransferase SLC1
Protein EntryPLSC_YEAST
UniProt IDP33333
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
DomainThe HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. {ECO:0000250}.
FunctionMay be an acyltransferase with an altered substrate specificity that enables it to use a C-26-CoA in place of the C-16 or C-18-CoAs used by the wild-type protein.
InteractionQ12168:ACF2; NbExp=1; IntAct=EBI-13494, EBI-32973; P25376:AGP1; NbExp=1; IntAct=EBI-13494, EBI-2357; P40471:AYR1; NbExp=1; IntAct=EBI-13494, EBI-25213; P08456:CHO1; NbExp=1; IntAct=EBI-13494, EBI-14055; P10614:ERG11; NbExp=1; IntAct=EBI-13494, EBI-5127; P38604:ERG7; NbExp=1; IntAct=EBI-13494, EBI-6572; P38225:FAT1; NbExp=1; IntAct=EBI-13494, EBI-6819; P19145:GAP1; NbExp=1; IntAct=EBI-13494, EBI-7314; P35844:KES1; NbExp=1; IntAct=EBI-13494, EBI-9648; P53224:ORM1; NbExp=1; IntAct=EBI-13494, EBI-12592; P41543:OST1; NbExp=1; IntAct=EBI-13494, EBI-12651; P25297:PHO84; NbExp=1; IntAct=EBI-13494, EBI-13320; P40975:PMP2; NbExp=1; IntAct=EBI-13494, EBI-2043041; P87284:PMP3; NbExp=1; IntAct=EBI-13494, EBI-13555; P35196:RER2; NbExp=1; IntAct=EBI-13494, EBI-14943; Q04947:RTN1; NbExp=1; IntAct=EBI-13494, EBI-38020; P32368:SAC1; NbExp=1; IntAct=EBI-13494, EBI-16210; P14359:SNA3; NbExp=1; IntAct=EBI-13494, EBI-26122; P39986:SPF1; NbExp=1; IntAct=EBI-13494, EBI-3128; P25037:UBP1; NbExp=1; IntAct=EBI-13494, EBI-19819; P28321:YJU3; NbExp=1; IntAct=EBI-13494, EBI-26790; P28625:YMR152W; NbExp=1; IntAct=EBI-13494, EBI-27313;
PathwayPhospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
SimilarityBelongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.