LMPD Database

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LMP007227

UniProt Annotations

Entry Information
Gene NameNsg2p
Protein EntryNSG2_YEAST
UniProt IDP53898
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionStabilizes the HMG-CoA reductase HMG2 by preventing its HRD1-dependent degradation. Binds directly to the sterol-sensing domain (SSD)-containing transmembrane region of HMG2, promoting its folding to protect it from degradation
FunctionStabilizes the HMG-CoA reductase HMG2 by preventing its HRD1-dependent degradation. Binds directly to the sterol-sensing domain (SSD)-containing transmembrane region of HMG2, promoting its folding to protect it from degradation. {ECO:0000269|PubMed:16270032}.
MiscellaneousPresent with 3390 molecules/cell in log phase SD medium
MiscellaneousPresent with 3390 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityTo yeast YHR133c
SimilarityTo yeast YHR133c. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16270032}; Multi- pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16270032}.
Subcellular LocationEndoplasmic reticulum membrane ; Multi- pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16270032}.