LMPD Database

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LMP007234

UniProt Annotations

Entry Information
Gene NameTcb3p
Protein EntryTCB3_YEAST
UniProt IDQ03640
SpeciesYeast (S288c)
Comments
Comment typeDescription
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains. {ECO:0000250};
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains. ;
DomainThe C-terminal C2 domain shows Ca(2+)-dependent phospholipid binding. It binds to phosphatidylserine, phosphatidylinositol and various phosphoinositides. The other C2 domains do not retain all 5 conserved Asp residues found in calcium-binding C2 domains.
FunctionMay play a role in membrane trafficking
FunctionMay play a role in membrane trafficking. {ECO:0000269|PubMed:15049706, ECO:0000269|PubMed:15141306}.
InteractionSelf; NbExp=1; IntAct=EBI-27872, EBI-27872; P53388:DIP5; NbExp=1; IntAct=EBI-27872, EBI-5904; P33413:DUR3; NbExp=1; IntAct=EBI-27872, EBI-2060312; Q08967:FLC1; NbExp=1; IntAct=EBI-27872, EBI-36673; Q07651:FMP45; NbExp=1; IntAct=EBI-27872, EBI-2051056; P40088:FTR1; NbExp=1; IntAct=EBI-27872, EBI-7138; P10823:GPA2; NbExp=1; IntAct=EBI-27872, EBI-7382; P19807:HNM1; NbExp=1; IntAct=EBI-27872, EBI-8409; P25619:HSP30; NbExp=1; IntAct=EBI-27872, EBI-8563; P32465:HXT1; NbExp=1; IntAct=EBI-27872, EBI-8759; P23585:HXT2; NbExp=1; IntAct=EBI-27872, EBI-2054100; P32466:HXT3; NbExp=1; IntAct=EBI-27872, EBI-8770; P38695:HXT5; NbExp=1; IntAct=EBI-27872, EBI-8778; P39004:HXT7; NbExp=1; IntAct=EBI-27872, EBI-8790; P38250:IST2; NbExp=1; IntAct=EBI-27872, EBI-21520; P30605:ITR1; NbExp=1; IntAct=EBI-27872, EBI-2050956; P40260:MEP1; NbExp=1; IntAct=EBI-27872, EBI-10714; P53390:MEP3; NbExp=1; IntAct=EBI-27872, EBI-10729; P36027:MID2; NbExp=1; IntAct=EBI-27872, EBI-10901; P50276:MUP1; NbExp=1; IntAct=EBI-27872, EBI-11624; P38755:OSH7; NbExp=1; IntAct=EBI-27872, EBI-12641; Q02785:PDR12; NbExp=1; IntAct=EBI-27872, EBI-13065; P25297:PHO84; NbExp=1; IntAct=EBI-27872, EBI-13320; P06197:PIS1; NbExp=1; IntAct=EBI-27872, EBI-13458; Q04383:PLM2; NbExp=1; IntAct=EBI-27872, EBI-2079237; P40975:PMP2; NbExp=1; IntAct=EBI-27872, EBI-2043041; P87284:PMP3; NbExp=1; IntAct=EBI-27872, EBI-13555; Q12335:PST2; NbExp=1; IntAct=EBI-27872, EBI-14064; P40474:QDR2; NbExp=1; IntAct=EBI-27872, EBI-25203; P38234:RFS1; NbExp=1; IntAct=EBI-27872, EBI-21445; P32445:RIM1; NbExp=1; IntAct=EBI-27872, EBI-15206; Q03516:RSN1; NbExp=1; IntAct=EBI-27872, EBI-27593; Q04947:RTN1; NbExp=1; IntAct=EBI-27872, EBI-38020; P53172:SDS23; NbExp=1; IntAct=EBI-27872, EBI-23782; P35735:SFK1; NbExp=1; IntAct=EBI-27872, EBI-26678; P32568:SNQ2; NbExp=1; IntAct=EBI-27872, EBI-17590; Q12466:TCB1; NbExp=1; IntAct=EBI-27872, EBI-34614; P48231:TCB2; NbExp=1; IntAct=EBI-27872, EBI-28779; Q07824:TPO1; NbExp=1; IntAct=EBI-27872, EBI-38106; P53283:TPO2; NbExp=1; IntAct=EBI-27872, EBI-2044753; Q06451:TPO3; NbExp=1; IntAct=EBI-27872, EBI-34275; Q12256:TPO4; NbExp=1; IntAct=EBI-27872, EBI-37213; P53241:VHT1; NbExp=1; IntAct=EBI-27872, EBI-20297; P53832:WSC2; NbExp=1; IntAct=EBI-27872, EBI-2055941; Q12215:WSC3; NbExp=1; IntAct=EBI-27872, EBI-20551; Q3E756:YBL029C-A; NbExp=1; IntAct=EBI-27872, EBI-2044812; Q06170:YLR326W; NbExp=1; IntAct=EBI-27872, EBI-35994; Q06689:YLR413W; NbExp=1; IntAct=EBI-27872, EBI-38659; Q12402:YOP1; NbExp=1; IntAct=EBI-27872, EBI-37092; P53049:YOR1; NbExp=1; IntAct=EBI-27872, EBI-29324;
MiscellaneousPresent with 4280 molecules/cell in log phase SD medium
MiscellaneousPresent with 4280 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the tricalbin family
SimilarityBelongs to the tricalbin family. {ECO:0000305}.
SimilarityContains 3 C2 domains. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Subcellular LocationCell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Subcellular LocationCell membrane ; Multi-pass membrane protein .
SubunitInteracts with TCB2 via its C-terminal domain
SubunitInteracts with TCB2 via its C-terminal domain. {ECO:0000269|PubMed:15141306}.