LMPD Database

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LMP007248

UniProt Annotations

Entry Information
Gene NameYju3p
Protein EntryMGLL_YEAST
UniProt IDP28321
SpeciesYeast (S288c)
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=260 uM for rac-1(3)-oleoylglycerol {ECO:0000269|PubMed:20554061}; Vmax=10.3 mmol/h/mg enzyme {ECO:0000269|PubMed:20554061}; pH dependence: Active from pH 4.5 to 8. {ECO:0000269|PubMed:20554061};
Catalytic ActivityHydrolyzes glycerol monoesters of long-chain fatty acids.
FunctionConverts monoacylglycerides (MAG) to free fatty acids and glycerol. Required for efficient degradation of MAG, short- lived intermediates of glycerolipid metabolism which may also function as lipid signaling molecules. Controls inactivation of the signaling lipid N-palmitoylethanolamine (PEA). {ECO:0000269|PubMed:19529773, ECO:0000269|PubMed:20554061}.
MiscellaneousPresent with 2140 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayGlycerolipid metabolism; triacylglycerol degradation.
SimilarityBelongs to the AB hydrolase superfamily. Monoacylglycerol lipase family. {ECO:0000305}.
Subcellular LocationCytoplasm. Endoplasmic reticulum. Lipid droplet. Mitochondrion outer membrane. Note=Although the protein was identified in the cytoplasm, several membrane systems and lipid droplets, MGL activity was only measured in membrane fractions and lipid droplets.