LMPD Database

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LMP007255

UniProt Annotations

Entry Information
Gene Namedelta(14)-sterol reductase
Protein EntryERG24_YEAST
UniProt IDP32462
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity4,4-dimethyl-5-alpha-cholesta-8,24-dien-3- beta-ol + NADP(+) = 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3- beta-ol + NADPH.
Enzyme RegulationInhibited by the morpholine antifungal drug fenpropimorph.
FunctionReduces the C14=C15 double bond of 4,4-dimethyl- cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24- dienol.
MiscellaneousPresent with 1600 molecules/cell in log phase SD medium
MiscellaneousPresent with 1600 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwaySteroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 2/6.
SimilarityBelongs to the ERG4/ERG24 family
SimilarityBelongs to the ERG4/ERG24 family. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.