LMPD Database

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LMP007258

UniProt Annotations

Entry Information
Gene Nameacetyl-CoA carboxylase ACC1
Protein EntryACAC_YEAST
UniProt IDQ00955
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.
Catalytic ActivityATP + biotin-[carboxyl-carrier-protein] + CO(2) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier- protein].
CofactorName=biotin; Xref=ChEBI:CHEBI:57586; Evidence={ECO:0000250}; Note=Biotin. {ECO:0000250};
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 2 manganese ions per subunit. {ECO:0000250};
Enzyme RegulationBy phosphorylation. The catalytic activity is inhibited by soraphen A, a polyketide isolated from the myxobacterium Sorangium cellulosum and a potent inhibitor of fungal growth. {ECO:0000269|PubMed:7916271}.
FunctionCarries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole. {ECO:0000269|PubMed:10757783, ECO:0000269|PubMed:12730220, ECO:0000269|PubMed:6103540, ECO:0000269|PubMed:6108218, ECO:0000269|PubMed:8943372}.
InductionRepressed in presence of fatty acids. Repressed 3-fold by lipid precursors, inositol and choline, and also controlled by regulatory factors INO2, INO4 and OPI1. {ECO:0000269|PubMed:1359536, ECO:0000269|PubMed:8098706, ECO:0000269|PubMed:8127678}.
MiscellaneousPresent with 20200 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayLipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
SimilarityContains 1 ATP-grasp domain. {ECO:0000255|PROSITE- ProRule:PRU00409}.
SimilarityContains 1 biotin carboxylation domain. {ECO:0000305}.
SimilarityContains 1 biotinyl-binding domain. {ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000305}.
SimilarityContains 1 carboxyltransferase domain. {ECO:0000305}.
Subcellular LocationCytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
SubunitHomodimer. {ECO:0000269|PubMed:12663926, ECO:0000269|PubMed:15079078, ECO:0000269|PubMed:15610732}.