LMPD Database

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LMP007262

UniProt Annotations

Entry Information
Gene Nameinositol polyphosphate multikinase
Protein EntryIPMK_YEAST
UniProt IDP07250
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108;
FunctionHas kinase activity and phosphorylates inositol 1,4,5- trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,5- tetrakisphosphate (Ins(1,3,4,5)P4). Has low kinase activity towards InsP6. With ARG80, ARG81 and MCM1, coordinates the expression of arginine anabolic and catabolic genes in response to arginine. Recruites ARG80 and MCM21 to stabilize them. {ECO:0000269|PubMed:10574768, ECO:0000269|PubMed:10632874}.
MiscellaneousPresent with 2720 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
MiscellaneousThe expression of this protein is not effected by the presence of arginine.
SimilarityBelongs to the inositol phosphokinase (IPK) family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000269|PubMed:10632874}.
SubunitInteracts with ARG80 and MCM1. {ECO:0000269|PubMed:10632874, ECO:0000269|PubMed:17050532}.