LMPD Database

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LMP007264

UniProt Annotations

Entry Information
Gene Nameoxysterol-binding protein related protein OSH2
Protein EntryOSH2_YEAST
UniProt IDQ12451
SpeciesYeast (S288c)
Comments
Comment typeDescription
DomainThe FFAT motif is required for interaction with SCS2 and proper localization of the protein. {ECO:0000269|PubMed:12727870}.
FunctionLipid-binding protein involved in maintenance of intracellular sterol distribution and homeostasis. Binds to phosphoinositides. {ECO:0000269|PubMed:15173322}.
InteractionP36006:MYO3; NbExp=3; IntAct=EBI-12621, EBI-11670; Q04439:MYO5; NbExp=6; IntAct=EBI-12621, EBI-11687;
MiscellaneousPresent with 1069 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the OSBP family. {ECO:0000305}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 2 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:11408574, ECO:0000269|PubMed:12727870}; Peripheral membrane protein {ECO:0000269|PubMed:11408574, ECO:0000269|PubMed:12727870}. Note=Cell periphery, enriched in small buds of G1 phase cells and near the bud-neck region of S phase cells.