LMPD Database

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LMP007265

UniProt Annotations

Entry Information
Gene Nameaminophospholipid-translocating P4-type ATPase DNF2
Protein EntryATC4_YEAST
UniProt IDQ12675
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
FunctionThis magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids. Required for protein transport from Golgi to vacuoles. {ECO:0000269|PubMed:12221123}.
PtmPhosphorylated by FPK1 and KIN82. {ECO:0000269|PubMed:15665377, ECO:0000269|PubMed:17330950, ECO:0000269|PubMed:18199685, ECO:0000269|PubMed:18407956, ECO:0000269|PubMed:19779198}.
SimilarityBelongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:12221123, ECO:0000269|PubMed:18199685}; Multi-pass membrane protein {ECO:0000269|PubMed:12221123, ECO:0000269|PubMed:18199685}.