LMPD Database

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LMP007274

UniProt Annotations

Entry Information
Gene Name1-phosphatidylinositol 4-kinase
Protein EntryPIK1_YEAST
UniProt IDP39104
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
FunctionActs on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,- trisphosphate. PIK1 is part of a nuclear phosphoinositide cycle and could control cytokinesis through the actin cytoskeleton.
InteractionQ06389:FRQ1; NbExp=3; IntAct=EBI-13423, EBI-11946;
MiscellaneousPresent with 1600 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the PI3/PI4-kinase family. Type III PI4K subfamily. {ECO:0000305}.
SimilarityContains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
SimilarityContains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
Subcellular LocationNucleus.
SubunitInteracts with FRQ1. {ECO:0000269|PubMed:10559922}.