LMPD Database

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LMP007299

UniProt Annotations

Entry Information
Gene Namelysophosphatidic acid acyltransferase LOA1
Protein EntryLOA1_YEAST
UniProt IDQ06508
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. {ECO:0000269|PubMed:22090344}.
FunctionAcyl-CoA-dependent lysophosphatidic acid acyltransferase with preference for oleoyl-CoA. Involved in triacylglyceride homeostasis and lipid droplet formation. Involved in vacuolar protein sorting. {ECO:0000269|PubMed:12134085, ECO:0000269|PubMed:22090344}.
MiscellaneousPresent with 6630 molecules/cell in log phase SD medium
MiscellaneousPresent with 6630 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family
SimilarityBelongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}.
Subcellular LocationLipid droplet {ECO:0000269|PubMed:21820081, ECO:0000269|PubMed:22090344}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Lipid droplets consist of a surface phospholipid monolayer and a hydrophobic interior. The latter makes embedding of proteins containing transmembrane segments difficult, and these may instead adopt a hairpin or monotonic conformation when associated with lipid droplet membranes. Always localizes to lipid droplets, irrespective of whether cells are grown on glucose or oleate.
Subcellular LocationLipid droplet {ECO:0000269|PubMed:21820081, ECO:0000269|PubMed:22090344}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein . Note=Lipid droplets consist of a surface phospholipid monolayer and a hydrophobic interior. The latter makes embedding of proteins containing transmembrane segments difficult, and these may instead adopt a hairpin or monotonic conformation when associated with lipid droplet membranes. Always localizes to lipid droplets, irrespective of whether cells are grown on glucose or oleate.