LMPD Database

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LMP007300

UniProt Annotations

Entry Information
Gene Namelanosterol synthase ERG7
Protein EntryERG7_YEAST
UniProt IDP38604
SpeciesYeast (S288c)
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 7. {ECO:0000269|PubMed:1731628}; Temperature dependence: Optimum temperature is 35 degrees Celsius. {ECO:0000269|PubMed:1731628};
Biophysicochemical PropertiespH dependence: Optimum pH is 7. ; Temperature dependence: Optimum temperature is 35 degrees Celsius. ;
Catalytic Activity(3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol.
Enzyme RegulationERG27 is required for activity
Enzyme RegulationERG27 is required for activity. {ECO:0000269|PubMed:12842197}.
FunctionCatalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.
InteractionQ12452:ERG27; NbExp=4; IntAct=EBI-6572, EBI-38132;
MiscellaneousPresent with 2193 molecules/cell in log phase SD medium
MiscellaneousPresent with 2193 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayTerpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 3/3.
SimilarityBelongs to the terpene cyclase/mutase family
SimilarityBelongs to the terpene cyclase/mutase family. {ECO:0000305}.
SimilarityContains 3 PFTB repeats
SimilarityContains 3 PFTB repeats. {ECO:0000305}.
Subcellular LocationLipid droplet. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Predominantly in lipid particles.