LMP007315 UniProt Annotations
Gene Name phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52 Protein Entry INP52_YEAST UniProt ID P50942 Species Yeast (S288c)
Comment type Description Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. Domain The SAC1 domain is capable of hydrolyzing phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) Domain The SAC1 domain is capable of hydrolyzing phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). {ECO:0000269|PubMed:10224048}. Function Dephosphorylates a number of phosphatidylinositols (PIs) like phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), but also phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5- bisphosphate. Specifically functions within the early endocytic pathway and actin organization. {ECO:0000269|PubMed:10224048, ECO:0000269|PubMed:10625610, ECO:0000269|PubMed:10962003, ECO:0000269|PubMed:11094088, ECO:0000269|PubMed:11311145, ECO:0000269|PubMed:15169871, ECO:0000269|PubMed:15691741, ECO:0000269|PubMed:15798181, ECO:0000269|PubMed:16406366, ECO:0000269|PubMed:17452534, ECO:0000269|PubMed:9265642, ECO:0000269|PubMed:9560389, ECO:0000269|PubMed:9788876}. Interaction P15891:ABP1; NbExp=2; IntAct=EBI-28834, EBI-2036; Q06604:BSP1; NbExp=4; IntAct=EBI-28834, EBI-37047; P32790:SLA1; NbExp=3; IntAct=EBI-28834, EBI-17313; Similarity Belongs to the synaptojanin family Similarity Belongs to the synaptojanin family. {ECO:0000305}. Similarity Contains 1 SAC domain. {ECO:0000255|PROSITE- ProRule:PRU00183}. Similarity In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family Similarity In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. {ECO:0000305}. Subcellular Location Cytoplasm, cytoskeleton, actin patch {ECO:0000269|PubMed:11094088, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15798181, ECO:0000269|PubMed:16406366}. Subunit Interacts with ABP1 and BSP1 Subunit Interacts with ABP1 and BSP1. {ECO:0000269|PubMed:12606027, ECO:0000269|PubMed:15798181}.
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