LMPD Database

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LMP007317

UniProt Annotations

Entry Information
Gene NamePil1p
Protein EntryPIL1_YEAST
UniProt IDP53252
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionNegative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress
FunctionNegative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress. {ECO:0000269|PubMed:15016821}.
InteractionP35719:MRP8; NbExp=3; IntAct=EBI-23225, EBI-16255;
MiscellaneousPresent with 2157 molecules/cell in log phase SD medium
MiscellaneousPresent with 2157 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PtmPhosphorylated by PKH1 and PKH2. Phosphorylation is inhibited by sphingolipid long chain bases (LCBs). {ECO:0000269|PubMed:15016821, ECO:0000269|PubMed:15665377, ECO:0000269|PubMed:17330950, ECO:0000269|PubMed:17761666, ECO:0000269|PubMed:18407956, ECO:0000269|PubMed:19779198}.
Subcellular LocationLipid droplet .
Subcellular LocationLipid droplet {ECO:0000269|PubMed:14562095}.