LMPD Database

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LMP007323

UniProt Annotations

Entry Information
Gene NameTcb1p
Protein EntryTCB1_YEAST
UniProt IDQ12466
SpeciesYeast (S288c)
Comments
Comment typeDescription
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains. {ECO:0000250};
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains. ;
DomainThe C-terminal C2 domain shows Ca(2+)-dependent phospholipid binding. It binds to phosphatidylserine, phosphatidylinositol and various phosphoinositides. The other C2 domains do not retain all 5 conserved Asp residues found in calcium-binding C2 domains.
FunctionMay play a role in membrane trafficking
FunctionMay play a role in membrane trafficking. {ECO:0000269|PubMed:15049706, ECO:0000269|PubMed:15141306}.
InteractionP43603:LSB3; NbExp=1; IntAct=EBI-34614, EBI-22980; Q03640:TCB3; NbExp=1; IntAct=EBI-34614, EBI-27872;
MiscellaneousPresent with 6140 molecules/cell in log phase SD medium
MiscellaneousPresent with 6140 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the tricalbin family
SimilarityBelongs to the tricalbin family. {ECO:0000305}.
SimilarityContains 3 C2 domains. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein {ECO:0000269|PubMed:14562095}.
Subcellular LocationCell membrane ; Multi-pass membrane protein .
SubunitInteracts with TCB2 via its C-terminal domain
SubunitInteracts with TCB2 via its C-terminal domain. {ECO:0000269|PubMed:15141306}.