LMPD Database

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LMP007343

UniProt Annotations

Entry Information
Gene NameTcb2p
Protein EntryTCB2_YEAST
UniProt IDP48231
SpeciesYeast (S288c)
Comments
Comment typeDescription
DomainThe C2 domains show Ca(2+)-independent phospholipid binding. None of the C2 domains retains all 5 conserved Asp residues found in calcium-binding C2 domains.
FunctionMay play a role in membrane trafficking. {ECO:0000269|PubMed:15049706, ECO:0000269|PubMed:15141306}.
InteractionQ03640:TCB3; NbExp=1; IntAct=EBI-28779, EBI-27872; Q07824:TPO1; NbExp=1; IntAct=EBI-28779, EBI-38106;
MiscellaneousPresent with 2630 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the tricalbin family. {ECO:0000305}.
SimilarityContains 3 C2 domains. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Subcellular LocationCell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Traffics from the cell surface to intracellular vesicles near the vacuole. {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15141306}.
SubunitInteracts with TCB1 and TCB3 via its C-terminal domain. {ECO:0000269|PubMed:15141306}.