LMPD Database

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LMP007344

UniProt Annotations

Entry Information
Gene Nameserine C-palmitoyltransferase LCB2
Protein EntryLCB2_YEAST
UniProt IDP40970
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityPalmitoyl-CoA + L-serine = CoA + 3-dehydro-D- sphinganine + CO(2). {ECO:0000269|PubMed:10713067, ECO:0000269|PubMed:11781309, ECO:0000269|PubMed:15485854, ECO:0000269|PubMed:8058731, ECO:0000269|PubMed:8063782}.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
FunctionCatalytic subunit of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine.
InteractionP25045:LCB1; NbExp=9; IntAct=EBI-10067, EBI-10059;
MiscellaneousPresent with 54500 molecules/cell in log phase SD medium
MiscellaneousPresent with 54500 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayLipid metabolism; sphingolipid metabolism.
SimilarityBelongs to the class-II pyridoxal-phosphate-dependent aminotransferase family
SimilarityBelongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. {ECO:0000305}.
Subcellular LocationCytoplasm. Endoplasmic reticulum. Membrane {ECO:0000305}; Multi-pass membrane protein .
Subcellular LocationCytoplasm. Endoplasmic reticulum. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
SubunitLCB1 and LCB2 encode essential subunits of the enzyme and form a heterodimer. Component of the SPOTS complex, at least composed of LCB1/2 (LCB1 and/or LCB2), ORM1/2 (ORM1 and/or ORM2), SAC1 and TSC3. Interacts with LCB1 and TSC3. {ECO:0000269|PubMed:10713067, ECO:0000269|PubMed:11781309, ECO:0000269|PubMed:15485854, ECO:0000269|PubMed:20182505, ECO:0000269|PubMed:8058731}.