LMPD Database

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LMP007350

UniProt Annotations

Entry Information
Gene Namebifunctional choline kinase/ethanolamine kinase CKI1
Protein EntryKICH_YEAST
UniProt IDP20485
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityATP + choline = ADP + phosphocholine.
FunctionResponsible for phosphatidylcholine synthesis via the CDP-choline pathway. Also exhibits ethanolamine kinase activity but at 14% efficiency compared with choline.
InteractionP25293:NAP1; NbExp=5; IntAct=EBI-9699, EBI-11850;
MiscellaneousPresent with 3930 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayPhospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1.
SimilarityBelongs to the choline/ethanolamine kinase family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitMonomer. Interacts with NAP1. {ECO:0000269|PubMed:18086883}.