LMPD Database

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LMP007354

UniProt Annotations

Entry Information
Gene Nameoxysterol-binding protein related protein SWH1
Protein EntryOSH1_YEAST
UniProt IDP35845
SpeciesYeast (S288c)
Comments
Comment typeDescription
DomainThe ankyrin repeats are required for targeting the protein to the NV junction. {ECO:0000269|PubMed:12727870}.
DomainThe FFAT motif is required for interaction with SCS2 and proper localization of the protein. {ECO:0000269|PubMed:12727870}.
DomainThe PH domain is required for targeting the protein to the late Golgi. {ECO:0000269|PubMed:12727870}.
FunctionLipid-binding protein involved in maintenance of intracellular sterol distribution and homeostasis. Binds to phosphoinositides. May be involved in formation of PMN vesicles by altering the membrane lipid composition. {ECO:0000269|PubMed:15173322}.
SimilarityBelongs to the OSBP family. {ECO:0000305}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 3 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular LocationCytoplasm. Golgi apparatus membrane. Nucleus outer membrane. Note=Soluble protein that accumulates on the surface of late Golgi membranes and at nucleus-vacuole (NV) junctions, interorganelle interfaces between the nuclear envelope and the vacuole membrane formed during piecemeal microautophagy of the nucleus (PMN). Targeted exclusively to NV junctions in stationary phase.
SubunitInteracts with NVJ1. {ECO:0000269|PubMed:15367582}.