LMPD Database

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LMP007359

UniProt Annotations

Entry Information
Gene NameSrt1p
Protein EntrySRT1_YEAST
UniProt IDQ03175
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + ditrans,polycis-polyprenyl diphosphate (n = 10-55). {ECO:0000303|PubMed:25066056}.
FunctionWith NUS1, forms the dehydrodolichyl diphosphate syntase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). {ECO:0000269|PubMed:11442630, ECO:0000269|PubMed:17345630, ECO:0000269|PubMed:25066056}.
InductionExpression is induced in the stationary phase. {ECO:0000269|PubMed:11442630}.
PathwayProtein modification; protein glycosylation. {ECO:0000305}.
SimilarityBelongs to the UPP synthase family. {ECO:0000305}.
Subcellular LocationLipid droplet {ECO:0000269|PubMed:11442630}.
SubunitForms an active dehydrodolichyl diphosphate syntase complex with NUS1. {ECO:0000303|PubMed:25066056}.