LMPD Database

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LMP007377

UniProt Annotations

Entry Information
Gene Namealpha-ketoglutarate dehydrogenase KGD1
Protein EntryODO1_YEAST
UniProt IDP20967
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2).
CofactorName=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
Enzyme RegulationCatabolite repressed.
FunctionThe 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). {ECO:0000269|PubMed:11926067, ECO:0000269|PubMed:2503710, ECO:0000269|PubMed:8299151}.
MiscellaneousPresent with 14300 molecules/cell in log phase SD medium
MiscellaneousPresent with 14300 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the alpha-ketoglutarate dehydrogenase family
SimilarityBelongs to the alpha-ketoglutarate dehydrogenase family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid.