LMPD Database

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LMP007398

UniProt Annotations

Entry Information
Gene Namesterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)
Protein EntryERG26_YEAST
UniProt IDP53199
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityA 3-beta-hydroxysteroid-4-alpha-carboxylate + NAD(P)(+) = a 3-oxosteroid + CO(2) + NAD(P)H.
InteractionP40030:ERG28; NbExp=3; IntAct=EBI-6514, EBI-22518; P38132:MCM7; NbExp=2; IntAct=EBI-6514, EBI-4300;
MiscellaneousPresent with 2580 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwaySteroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 4/6.
SimilarityBelongs to the 3-beta-HSD family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:12119386, ECO:0000269|PubMed:15716577}; Peripheral membrane protein {ECO:0000269|PubMed:12119386, ECO:0000269|PubMed:15716577}.
SubunitHeterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation- related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum. {ECO:0000269|PubMed:12119386}.