LMPD Database

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LMP007409

UniProt Annotations

Entry Information
Gene Namelysophosphatidic acid acyltransferase ICT1
Protein EntryICT1_YEAST
UniProt IDQ12385
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
DomainThe HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate
DomainThe HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. {ECO:0000250}.
FunctionLysophosphatidic acid acyltransferase involved in membrane remodeling leading to increased organic solvent tolerance. Involved in resistance to azoles and copper. {ECO:0000269|PubMed:10628851, ECO:0000269|PubMed:11055939, ECO:0000269|PubMed:18252723, ECO:0000269|PubMed:9717239}.
MiscellaneousThe isooctane tolerance of organic-solvent tolerant strain KK-21 may result from the alteration of the expression of several genes including ICT1, due to the loss of their proper regulation.
SimilarityBelongs to the peptidase S33 family. ABHD4/ABHD5 subfamily
SimilarityBelongs to the peptidase S33 family. ABHD4/ABHD5 subfamily. {ECO:0000305}.