LMPD Database

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LMP007421

UniProt Annotations

Entry Information
Gene NamePfa3p
Protein EntryPFA3_YEAST
UniProt IDP42836
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityPalmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
DomainThe DHHC domain is required for palmitoyltransferase activity.
FunctionPalmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization
FunctionPalmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization. {ECO:0000269|PubMed:16186255}.
MiscellaneousPresent with 2133 molecules/cell in log phase SD medium
MiscellaneousPresent with 2133 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PtmAutopalmitoylated.
SimilarityBelongs to the DHHC palmitoyltransferase family. PFA3 subfamily
SimilarityBelongs to the DHHC palmitoyltransferase family. PFA3 subfamily. {ECO:0000305}.
SimilarityContains 1 DHHC-type zinc finger
SimilarityContains 1 DHHC-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00067}.
Subcellular LocationVacuole membrane {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16186255}; Multi- pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16186255}.
Subcellular LocationVacuole membrane ; Multi- pass membrane protein {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16186255}.