LMPD Database

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LMP007422

UniProt Annotations

Entry Information
Gene Namemevalonate kinase
Protein EntryKIME_YEAST
UniProt IDP07277
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityATP + (R)-mevalonate = ADP + (R)-5- phosphomevalonate.
Enzyme RegulationFarnesyl pyrophosphate and geranyl pyrophosphate inhibit mevalonate kinase by binding competitively at the ATP-binding site.
FunctionMay contribute to the regulation of the isoprenoid and sterol pathway in living cells.
FunctionRAR (regulation of autonomous replication) is a protein whose activity increases the mitotic stability of plasmids.
MiscellaneousPresent with 3300 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayIsoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
SimilarityBelongs to the GHMP kinase family. Mevalonate kinase subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer.