LMPD Database

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LMP007424

UniProt Annotations

Entry Information
Gene Namediacylglycerol O-acyltransferase
Protein EntryDGAT2_YEAST
UniProt IDQ08650
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol
Catalytic ActivityAcyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. {ECO:0000269|PubMed:20554061}.
Catalytic ActivityAcyl-CoA + 2-acylglycerol = CoA + diacylglycerol
Catalytic ActivityAcyl-CoA + 2-acylglycerol = CoA + diacylglycerol. {ECO:0000269|PubMed:20554061}.
FunctionCatalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for storage lipid synthesis. May be involved in lipid particle synthesis from the endoplasmic reticulum and ergosterol biosynthesis. Also has monoacylglycerol acyltransferase (MGAT) activity, catalyzing the acyl-CoA-dependent esterification of monoacylglycerol to diacylglycerol. {ECO:0000269|PubMed:11741946, ECO:0000269|PubMed:11751830, ECO:0000269|PubMed:11751875, ECO:0000269|PubMed:14640980, ECO:0000269|PubMed:15155725, ECO:0000269|PubMed:21321129}.
InteractionP06169:PDC1; NbExp=1; IntAct=EBI-33586, EBI-5687;
MiscellaneousPresent with 907 molecules/cell in log phase SD medium
MiscellaneousPresent with 907 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PathwayGlycerolipid metabolism; triacylglycerol biosynthesis.
SimilarityBelongs to the diacylglycerol acyltransferase family
SimilarityBelongs to the diacylglycerol acyltransferase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein. Lipid droplet.