LMPD Database

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LMP007458

UniProt Annotations

Entry Information
Gene Nametetrafunctional fatty acid synthase subunit FAS1
Protein EntryFAS1_YEAST
UniProt IDP07149
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityA (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O.
Catalytic ActivityAcetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein].
Catalytic ActivityAcetyl-CoA + n malonyl-CoA + 2n NADPH = long- chain-acyl-CoA + n CoA + n CO(2) + 2n NADP(+).
Catalytic ActivityAn acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.
Catalytic ActivityMalonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].
Catalytic ActivityOleoyl-[acyl-carrier-protein] + H(2)O = [acyl- carrier-protein] + oleate.
FunctionFatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.
InteractionP19097:FAS2; NbExp=3; IntAct=EBI-6795, EBI-6806;
MiscellaneousPresent with 91800 molecules/cell in log phase SD medium
MiscellaneousPresent with 91800 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Sequence CautionSequence=CAA27616.1; Type=Frameshift; Positions=1845, 1948, 2017; Evidence= ;
Sequence CautionSequence=CAA27616.1; Type=Frameshift; Positions=1845, 1948, 2017; Evidence={ECO:0000305};
SimilarityBelongs to the fungal fatty acid synthetase subunit beta family
SimilarityBelongs to the fungal fatty acid synthetase subunit beta family. {ECO:0000305}.
SimilarityContains 1 MaoC-like domain
SimilarityContains 1 MaoC-like domain. {ECO:0000305}.
Subunit[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).