LMPD Database

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LMP007464

UniProt Annotations

Entry Information
Gene Namephospholipase D
Protein EntrySPO14_YEAST
UniProt IDP36126
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityA phosphatidylcholine + H(2)O = choline + a phosphatidate.
Enzyme RegulationActivity is dependent of phosphatidylinositol 4,5-bisphosphate and the regulator SRF1. Inhibited by magnesium
Enzyme RegulationActivity is dependent of phosphatidylinositol 4,5-bisphosphate and the regulator SRF1. Inhibited by magnesium. {ECO:0000269|PubMed:21347278}.
FunctionRequired for meiosis and spore formation. Seems to be involved in the coordinate induction of late meiotic events. PLD activity is induced under sporulation conditions and seems to be necessary to complete the meiotic cycle, but not for vegetative cell growth. {ECO:0000269|PubMed:1582554, ECO:0000269|PubMed:21347278}.
MiscellaneousPresent with 49 molecules/cell in log phase SD medium
MiscellaneousPresent with 49 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Sequence CautionSequence=AAA74938.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Sequence CautionSequence=AAA74938.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the phospholipase D family
SimilarityBelongs to the phospholipase D family. {ECO:0000305}.
SimilarityContains 1 PH domain
SimilarityContains 1 PH domain. {ECO:0000305}.
SimilarityContains 1 PX (phox homology) domain
SimilarityContains 1 PX (phox homology) domain. {ECO:0000305}.
SimilarityContains 2 PLD phosphodiesterase domains
SimilarityContains 2 PLD phosphodiesterase domains. {ECO:0000255|PROSITE-ProRule:PRU00153}.
SubunitInteracts with SRF1
SubunitInteracts with SRF1. {ECO:0000269|PubMed:21347278}.