LMPD Database

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LMP007477

UniProt Annotations

Entry Information
Gene Namesphinganine kinase LCB5
Protein EntryLCB5_YEAST
UniProt IDQ06147
SpeciesYeast (S288c)
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=2 uM for dihydrosphingosine ;
Biophysicochemical PropertiesKinetic parameters: KM=2 uM for dihydrosphingosine {ECO:0000269|PubMed:9677363};
Catalytic ActivityATP + phytosphingosine = ADP + phytosphingosine 1-phosphate.
Catalytic ActivityATP + sphinganine = ADP + sphinganine 1- phosphate.
FunctionCatalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively. Redundant to LCB4, is only responsible for few percent of the total activity. Involved in the biosynthesis of sphingolipids and ceramides. Involved in heat-induced transient cell cycle arrest. Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling. Involved in heat-stress resistance. {ECO:0000269|PubMed:11056159, ECO:0000269|PubMed:11102354, ECO:0000269|PubMed:11278643, ECO:0000269|PubMed:12493772, ECO:0000269|PubMed:9677363}.
MiscellaneousPresent with 1760 molecules/cell in log phase SD medium
MiscellaneousPresent with 1760 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityContains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
Subcellular LocationGolgi apparatus membrane {ECO:0000269|PubMed:12493772}; Peripheral membrane protein {ECO:0000269|PubMed:12493772}.
Subcellular LocationGolgi apparatus membrane ; Peripheral membrane protein .