LMPD Database

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LMP007493

UniProt Annotations

Entry Information
Gene Namehydroxymethylglutaryl-CoA reductase (NADPH) HMG1
Protein EntryHMDH1_YEAST
UniProt IDP12683
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic Activity(R)-mevalonate + CoA + 2 NADP(+) = (S)-3- hydroxy-3-methylglutaryl-CoA + 2 NADPH. {ECO:0000255|PROSITE- ProRule:PRU10003}.
FunctionOne of 2 isozymes that catalyze the conversion of HMG- CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis. {ECO:0000269|PubMed:3526336, ECO:0000269|PubMed:9292983}.
InteractionP12684:HMG2; NbExp=3; IntAct=EBI-8377, EBI-8384;
PathwayMetabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.
SimilarityBelongs to the HMG-CoA reductase family. {ECO:0000305}.
SimilarityContains 1 SSD (sterol-sensing) domain. {ECO:0000255|PROSITE-ProRule:PRU00199}.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope.