LMPD Database

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LMP007503

UniProt Annotations

Entry Information
Gene NameEnt2p
Protein EntryENT2_YEAST
UniProt IDQ05785
SpeciesYeast (S288c)
Comments
Comment typeDescription
FunctionBinds to membranes enriched in phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin. {ECO:0000269|PubMed:10449404}.
MiscellaneousPresent with 1970 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
PtmPhosphorylated by PRK1. {ECO:0000269|PubMed:11694597, ECO:0000269|PubMed:17287358, ECO:0000269|PubMed:17330950, ECO:0000269|PubMed:18407956, ECO:0000269|PubMed:19779198}.
SimilarityBelongs to the epsin family. {ECO:0000305}.
SimilarityContains 1 ENTH (epsin N-terminal homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00243}.
SimilarityContains 2 UIM (ubiquitin-interacting motif) repeats. {ECO:0000255|PROSITE-ProRule:PRU00213}.
Subcellular LocationCytoplasm. Membrane; Peripheral membrane protein. Note=Localizes in a punctate pattern. Found in the actin cortical patches, although the majority is located at the cell periphery.