LMPD Database

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LMP007508

UniProt Annotations

Entry Information
Gene Namepyruvate dehydrogenase (acetyl-transferring) subunit E1 beta
Protein EntryODPB_YEAST
UniProt IDP32473
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityPyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
CofactorName=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
FunctionThe pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
MiscellaneousPresent with 9970 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
Subcellular LocationMitochondrion matrix.
SubunitPyruvate dehydrogenase (E1) is a tetramer of 2 alpha and 2 beta subunits. Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds.