LMPD Database

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LMP007513

UniProt Annotations

Entry Information
Gene Nametrans-2-enoyl-CoA reductase (NADPH) TSC13
Protein EntryTSC13_YEAST
UniProt IDQ99190
SpeciesYeast (S288c)
Comments
Comment typeDescription
Catalytic ActivityA very-long-chain acyl-CoA + NADP(+) = a very- long-chain trans-2,3-dehydroacyl-CoA + NADPH.
FunctionComponent of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long chain fatty acids (VLCFA) from palmitate. Catalyzes the last step in each elongation cycle that lengthens palmitate by two carbon units. VLCFAs serve as precursors for ceramide and sphingolipids. Required for normal biogenesis of piecemeal microautophagy of the nucleus (PMN) bleps and vesicles during nutrient stress
FunctionComponent of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long chain fatty acids (VLCFA) from palmitate. Catalyzes the last step in each elongation cycle that lengthens palmitate by two carbon units. VLCFAs serve as precursors for ceramide and sphingolipids. Required for normal biogenesis of piecemeal microautophagy of the nucleus (PMN) bleps and vesicles during nutrient stress. {ECO:0000269|PubMed:11113186, ECO:0000269|PubMed:15958487}.
MiscellaneousPresent with 23600 molecules/cell in log phase SD medium
MiscellaneousPresent with 23600 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.
SimilarityBelongs to the steroid 5-alpha reductase family
SimilarityBelongs to the steroid 5-alpha reductase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:11113186, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15958487}; Multi-pass membrane protein {ECO:0000269|PubMed:11113186, ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15958487}. Note=Accumulates at nucleus-vacuole (NV) junctions. Sequestred to NV junctions by NVJ1. Accumulates in nuclear PMN bleps and vesicles during stationary phase and nitrogen starvation.
SubunitInteracts with the fatty acid elongation system components ELO2 and ELO3. Interacts with NVJ1
SubunitInteracts with the fatty acid elongation system components ELO2 and ELO3. Interacts with NVJ1. {ECO:0000269|PubMed:11113186, ECO:0000269|PubMed:15958487}.