LMPD Database

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LMP007532

UniProt Annotations

Entry Information
Gene Nameglycerol 2-dehydrogenase (NADP(+)) GCY1
Protein EntryGCY1_YEAST
UniProt IDP14065
SpeciesYeast (S288c)
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=11.3 mM for D,L-glyceraldehyde {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=0.007 mM for NADPH {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=0.13 mM for p-nitrobenzaldehyde {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=5.2 mM for benzaldehyde {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=8.7 mM for phenylglyoxal {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=50 mM for acrolein {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=54 mM for butyraldehyde {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=0.724 mM for ethyl-4-chloro-3-oxo-butanoate {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; pH dependence: Optimum pH is 6.5. {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562};
Biophysicochemical PropertiesKinetic parameters: KM=11.3 mM for D,L-glyceraldehyde {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=0.007 mM for NADPH {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=0.13 mM for p-nitrobenzaldehyde {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=5.2 mM for benzaldehyde {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=8.7 mM for phenylglyoxal {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=50 mM for acrolein {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=54 mM for butyraldehyde {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; KM=0.724 mM for ethyl-4-chloro-3-oxo-butanoate {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}; pH dependence: Optimum pH is 6.5. {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562};
Catalytic ActivityGlycerol + NADP(+) = glycerone + NADPH. {ECO:0000269|PubMed:10818358, ECO:0000269|PubMed:11306085, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:23770562}.
FunctionGlycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. Has mRNA binding activity. {ECO:0000269|PubMed:11113971, ECO:0000269|PubMed:15127164, ECO:0000269|PubMed:17140678, ECO:0000269|PubMed:22979944, ECO:0000269|PubMed:23770562, ECO:0000269|PubMed:23896974}.
InductionExpression is under the control of GAL4 and REB1, and is both positively controlled by galactose and negatively by glucose. Also induced by salt stress and in response to DNA replication stress. {ECO:0000269|PubMed:12536147, ECO:0000269|PubMed:2199324, ECO:0000269|PubMed:22842922, ECO:0000269|PubMed:9038161, ECO:0000269|PubMed:9435793}.
SimilarityBelongs to the aldo/keto reductase family
SimilarityBelongs to the aldo/keto reductase family. {ECO:0000305}.
Subcellular LocationCytoplasm.