LMPD Database

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LMP007568

UniProt Annotations

Entry Information
Gene Namesn-glycerol-3-phosphate ABC transporter ATPase
Protein EntryUGPC_ECOLI
UniProt IDP10907
SpeciesE. coli
Comments
Comment typeDescription
Catalytic ActivityATP + H(2)O + glycerol-3-phosphate(Out) = ADP + phosphate + glycerol-3-phosphate(In). {ECO:0000255|HAMAP- Rule:MF_01727}.
Enzyme RegulationActivated by gluconate, inhibited by fumarate and internal phosphate. Internal phosphate may bind to UgpC and reduce its affinity for UgpA and UgpE. {ECO:0000269|PubMed:363686}.
FunctionPart of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system (Probable). Can also transport glycerophosphoryl diesters. {ECO:0000255|HAMAP-Rule:MF_01727, ECO:0000269|PubMed:2842304, ECO:0000269|PubMed:363686, ECO:0000269|PubMed:7042685, ECO:0000269|PubMed:8282692, ECO:0000269|PubMed:8407831, ECO:0000305}.
InductionInduced by phosphate starvation, via PhoB. Also induced by carbon starvation, via the cAMP receptor protein (CRP). {ECO:0000269|PubMed:1987150, ECO:0000269|PubMed:2842304, ECO:0000269|PubMed:7042685}.
MiscellaneousFunctional exchangeability of MalK and UgpC. But UgpC does not complement the regulatory function of MalK.
Sequence CautionSequence=AAB18425.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityBelongs to the ABC transporter superfamily. sn- glycerol-3-phosphate importer (TC 3.A.1.1.3) family. {ECO:0000255|HAMAP-Rule:MF_01727}.
SimilarityContains 1 ABC transporter domain. {ECO:0000255|HAMAP- Rule:MF_01727}.
Subcellular LocationCell inner membrane; Peripheral membrane protein.
SubunitThe complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute- binding protein (UgpB). {ECO:0000255|HAMAP-Rule:MF_01727}.