LMPD Database

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LMP007630

UniProt Annotations

Entry Information
Gene Namedihydrolipoyl dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes; glycine cleavage system L protein; dihydrolipoamide dehydrogenase
Protein EntryDLDH_ECOLI
UniProt IDP0A9P0
SpeciesE. coli
Comments
Comment typeDescription
Catalytic ActivityProtein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250}; Note=Binds 1 FAD per subunit. {ECO:0000250};
FunctionLipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes.
InteractionSelf; NbExp=2; IntAct=EBI-542856, EBI-542856; P06959:aceF; NbExp=3; IntAct=EBI-542856, EBI-542707; P03018:uvrD; NbExp=2; IntAct=EBI-542856, EBI-559573;
MiscellaneousThe active site is a redox-active disulfide bond.
Sequence CautionSequence=CAA24742.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:16079137}. Cell inner membrane {ECO:0000269|PubMed:16079137}; Peripheral membrane protein {ECO:0000269|PubMed:16079137}.
SubunitHomodimer.