LMPD Database

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LMP007767

UniProt Annotations

Entry Information
Gene Namefused 2-acylglycerophospho-ethanolamine acyl transferase/acyl-acyl carrier protein synthetase
Protein EntryAAS_ECOLI
UniProt IDP31119
SpeciesE. coli
Comments
Comment typeDescription
Catalytic ActivityAcyl-[acyl-carrier-protein] + O-(2-acyl-sn- glycero-3-phospho)ethanolamine = [acyl-carrier-protein] + O-(1- beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine. {ECO:0000255|HAMAP-Rule:MF_01162}.
Catalytic ActivityATP + an acid + [acyl-carrier-protein] = AMP + diphosphate + acyl-[acyl-carrier-protein]. {ECO:0000255|HAMAP- Rule:MF_01162}.
FunctionPlays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1. {ECO:0000255|HAMAP-Rule:MF_01162, ECO:0000269|PubMed:1649829}.
SimilarityIn the C-terminal section; belongs to the ATP- dependent AMP-binding enzyme family. {ECO:0000255|HAMAP- Rule:MF_01162}.
SimilarityIn the N-terminal section; belongs to the 2-acyl-GPE acetyltransferase family. {ECO:0000255|HAMAP-Rule:MF_01162}.
Subcellular LocationCell inner membrane; Multi-pass membrane protein.