LMPD Database

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LMP007781

UniProt Annotations

Entry Information
Gene Name3-oxoacyl-[acyl-carrier-protein] synthase III
Protein EntryFABH_ECOLI
UniProt IDP0A6R0
SpeciesE. coli
Comments
Comment typeDescription
Catalytic ActivityAcetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO(2).
DomainThe last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. {ECO:0000269|PubMed:11078736}.
Enzyme RegulationNegatively regulated by acyl-ACP, possibly by binding to either the free enzyme or the acyl-enzyme intermediate. {ECO:0000269|PubMed:8631920}.
FunctionCatalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for acetyl-CoA. Its substrate specificity determines the biosynthesis of straight-chain of fatty acids instead of branched-chain.
MiscellaneousInhibited by the SB418011 antibiotic. Not inhibited by cerulenin and thiolactomycin.
PathwayLipid metabolism; fatty acid biosynthesis.
SimilarityBelongs to the FabH family. {ECO:0000305}.
Subcellular LocationCytoplasm.
SubunitHomodimer.