LMPD Database

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LMP007804

UniProt Annotations

Entry Information
Gene NameProtein SPL-1
Protein EntrySGPL_CAEEL
UniProt IDQ9Y194
SpeciesC. elegans
Comments
Comment typeDescription
Catalytic ActivitySphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde. {ECO:0000269|PubMed:12682045}.
CofactorName=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250};
Developmental StageFound in the majority of L1 larvae and in all L2, L3 and L4 larvae and adults showing medium to high expression. Highest levels found in older adults. {ECO:0000269|PubMed:12682045}.
FunctionCleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Essential for normal development, intestinal integrity, growth and reproduction. {ECO:0000269|PubMed:12682045}.
PathwayLipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:12682045}.
SimilarityBelongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
Tissue SpecificityHigh expression found in the intestinal cells and faint expression in the head. {ECO:0000269|PubMed:12682045}.