LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP007823

UniProt Annotations

Entry Information
Gene NameProtein SMS-3
Protein EntryQ965Q4_CAEEL
UniProt IDQ965Q4
SpeciesC. elegans
Comments
Comment typeDescription
Catalytic ActivityA ceramide + a phosphatidylcholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol.
FunctionBidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase (By similarity).
PathwayLipid metabolism; sphingolipid metabolism.
SimilarityBelongs to the sphingomyelin synthase family.
Subcellular LocationMembrane ; Multi-pass membrane protein .