LMPD Database

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LMP007865

UniProt Annotations

Entry Information
Gene NameProtein Y39E4A.3
Protein EntryODBA_CAEEL
UniProt IDO45924
SpeciesC. elegans
Comments
Comment typeDescription
Catalytic Activity3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine = [dihydrolipoyllysine-residue (2- methylpropanoyl)transferase] S-(2- methylpropanoyl)dihydrolipoyllysine + CO(2). {ECO:0000269|PubMed:15340492}.
CofactorName=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250};
FunctionThe branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Required for the production of the monomethyl branched-chain fatty acids (mmBCFAs) isopentadecanoate (C15iso) and isoheptadecanoate (C17iso). {ECO:0000250, ECO:0000269|PubMed:15340492}.
PathwayLipid metabolism; fatty acid biosynthesis. {ECO:0000269|PubMed:15340492}.
SimilarityBelongs to the BCKDHA family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000250}.