LMPD Database

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LMP007867

UniProt Annotations

Entry Information
Gene NameProtein OGDH-1
Protein EntryODO1_CAEEL
UniProt IDO61199
SpeciesC. elegans
Comments
Comment typeDescription
Catalytic Activity2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2). {ECO:0000250|UniProtKB:Q02218}.
CofactorName=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250|UniProtKB:Q02218};
FunctionThe 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). {ECO:0000250|UniProtKB:Q02218}.
SimilarityBelongs to the alpha-ketoglutarate dehydrogenase family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000250}.