LMPD Database

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LMP007889

UniProt Annotations

Entry Information
Gene NameProtein DAF-9
Protein EntryDAF9_CAEEL
UniProt IDH2KYS3
SpeciesC. elegans
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=a; IsoId=H2KYS3-1; Sequence=Displayed; Name=b; IsoId=H2KYS3-2; Sequence=VSP_045859;
Catalytic Activity5-beta-cholestane-3-alpha,7-alpha,12-alpha- triol + 3 NADPH + 3 O(2) = (25R)-3-alpha,7-alpha,12-alpha- trihydroxy-5-beta-cholestan-26-oate + 3 NADP(+) + 4 H(2)O. {ECO:0000269|PubMed:16529801}.
Catalytic Activity5-beta-cholestane-3-alpha,7-alpha,12-alpha- triol + NADPH + O(2) = (25R)-5-beta-cholestane-3-alpha,7-alpha,12- alpha,26-tetraol + NADP(+) + H(2)O. {ECO:0000269|PubMed:16529801}.
FunctionSterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten- 3-one and lathosterone to form their carboxylic acid derivatives delta(4)-dafachronic acid and delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. {ECO:0000269|PubMed:11782415, ECO:0000269|PubMed:16529801, ECO:0000269|PubMed:22505847}.
PathwaySteroid hormone biosynthesis; dafachronic acid biosynthesis. {ECO:0000269|PubMed:16529801}.
SimilarityBelongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.