LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP008031

UniProt Annotations

Entry Information
Gene NameProtein HEX-1
Protein EntryHEXA_CAEEL
UniProt IDQ22492
SpeciesC. elegans
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=1.1 mM for p-nitrophenyl-beta-N-acetylglucosaminide {ECO:0000269|PubMed:17636254}; pH dependence: Optimum pH is 5.5. {ECO:0000269|PubMed:17636254};
Catalytic ActivityHydrolysis of terminal non-reducing N-acetyl- D-hexosamine residues in N-acetyl-beta-D-hexosaminides. {ECO:0000269|PubMed:17636254}.
Developmental StageExpressed throughout the life cycle. {ECO:0000269|PubMed:17636254}.
Disruption PhenotypeWorms show reduced degradation of p- nitrophenyl-beta-N-acetylglucosaminide and no chitotriosidase activity. {ECO:0000269|PubMed:17636254}.
FunctionResponsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines. Degrades chitotriose. {ECO:0000269|PubMed:17636254}.
SimilarityBelongs to the glycosyl hydrolase 20 family. {ECO:0000305}.
Subcellular LocationLysosome {ECO:0000305}.
Tissue SpecificityExpressed in coelomocytes and neurons of the pharyngeal region and nerve cord. {ECO:0000269|PubMed:17636254}.