LMPD Database

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LMP008289

UniProt Annotations

Entry Information
Gene NameProtein CAV-2
Protein EntryCAV2_CAEEL
UniProt IDQ18879
SpeciesC. elegans
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=a; IsoId=Q18879-1; Sequence=Displayed; Name=b; IsoId=Q18879-2; Sequence=VSP_043963; Note=No experimental confirmation available.; Name=c; IsoId=Q18879-3; Sequence=VSP_043962; Note=No experimental confirmation available.; Name=d; IsoId=Q18879-4; Sequence=VSP_043964; Note=No experimental confirmation available.;
Disruption PhenotypeDefective in the apical uptake of lipid and protein trafficking. Reduced brood size thought to be due to attenuated nutrient supply. {ECO:0000269|PubMed:19158391}.
FunctionMay act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can regulate their activity. Thought to have a role in the uptake of lipids and proteins in the intestinal cells; operates in the apical uptake of lipid markers and trafficking of yolk proteins. Affects fecundity and egg laying. {ECO:0000269|PubMed:19158391, ECO:0000269|PubMed:19907693}.
SimilarityBelongs to the caveolin family. {ECO:0000305}.
Subcellular LocationGolgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Apical cell membrane {ECO:0000269|PubMed:19158391}. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). {ECO:0000250}.
SubunitHomooligomer. {ECO:0000250}.
Tissue SpecificityExpressed in intracellular bodies in intestinal cells. {ECO:0000269|PubMed:19158391}.