LMPD Database

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LMP008290

UniProt Annotations

Entry Information
Gene NameProtein NRF-5
Protein EntryQ93796_CAEEL
UniProt IDQ93796
SpeciesC. elegans
Comments
Comment typeDescription
Disruption PhenotypeIncreased resistance to fluoxetine-induced nose muscle contraction. Slow development, embryonic lethality and defect in yolk transport to oocytes leading to accumulation of yolk granules in the pseudocoelomic fluid and appearance of pale eggs. Reduced level of sensitivity to dihomo-gamma-linolenic acid- induced sterility. Cell corpses persist significantly longer than in the wild-type, indicating a cell corpse clearance defect. {ECO:0000269|PubMed:10488330, ECO:0000269|PubMed:16118202, ECO:0000269|PubMed:16487504, ECO:0000269|PubMed:22727700}.
FunctionPlays a role in the uptake of a range of molecules including phosphatidylserine, lipids and xenobiotic compounds from the intestine to surrounding tissues. Possesses lipid transfer activity. Mediates transport of lipids from intestine to reproductive tract. Binds phosphatidylserine. Plays a role in efficient clearance of cell corpses by mediating phosphatidylserine appearance on phagocytic cells, thus promoting phagocytic engulfment of apoptotic cells. Vital for embryonic development. {ECO:0000269|PubMed:10488330, ECO:0000269|PubMed:16487504, ECO:0000269|PubMed:22727700, ECO:0000305}.
SimilarityBelongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Subcellular LocationSecreted .
SubunitInteracts with ttr-52.
Tissue SpecificityExpressed in the body wall muscle cells and detected at the basal surface of pharyngeal cells and basal- lateral membranes of the intestine. {ECO:0000269|PubMed:16118202, ECO:0000269|PubMed:22727700}.